Building 1: Biotech Lab and Office Space in Sioux Falls

Pioneering Biotech Innovation

Over 15 years in the making

Opened in January 2025, Building 1 at the USD Discovery District is a 50,000-square-foot beacon of innovation in Sioux Falls, South Dakota. As the first building of the 80-acre research park, this state-of-the-art facility offers customizable lab and office spaces designed for biotech and life sciences pioneers. Home to tenants like OmegaQuant Analytics, Building 1 fosters collaboration among industry, academia, and government, driving breakthroughs that shape the future. Whether you need a lab and office combo or a fully built research lab, Building 1 has the infrastructure and location you need to thrive.

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Explore Available Square Footage

37,924 leasable square feet, including build-to-suit labs and cGMP-compliant suites for research and manufacturing, tailored to stringent biotech needs.

Why Lease Space in Sioux Falls

Located near USD’s Sioux Falls campus and the GEAR Center, enabling partnerships with researchers, students, and healthcare leaders like Sanford and Avera Health.

Tailored for Biotech, Life Science, and Research Teams

Access conference rooms, prototyping facilities, and university services to accelerate development and commercialization.

Advanced Wet Lab & Office Configurations

Completed 13% under budget by ISG and McGough Construction, Building 1 blends efficiency with cutting-edge functionality, supporting long-term growth.

The USD Discovery District’s Building 1 offers flexible lab space for lease, including fully customizable wet labs and office suites designed for growing biotech firms.
A Vision for Progress

Purpose-Built Facilities for Growth

Funded by $25 million, including $15 million from the South Dakota Legislature and $4 million from Sioux Falls, Building 1 is a cornerstone of a research park projected to generate 2,800 jobs and $314 million in economic impact. Designed by ISG, a leader in collaborative architecture, the two-story facility integrates private sector innovation with student workforce and research tools. Its strategic location west of the USD classroom building ensures accessibility while leaving space for future campus growth. Building 1 is more than a building—it’s a launchpad for South Dakota’s biotech revolution.

The front entrance of Building 1 at the USD Discovery District features immense natural light, ideal for collaborative biotech and life science companies.

First Floor Highlights

Common Spaces include conference room, restrooms (with showers), mail room and break room.

Available spaces include six offices in our co-working center and up to 6,000 leasable square footage.

Second Floor Highlights

Common Spaces include conference room, restroom (with showers), and wellness room.

Available spaces are up to 15,000 square footage.

Interested in Leasing?

Book a Tour of Buidling 1

Looking for biotech lab space in Sioux Falls? With 37,924 leasable square feet, Building 1 is South Dakota’s most advanced life sciences facility.

Sioux Falls

4600 West Nobel Street, Suite 102
Sioux Falls, SD 57107

605.275.8010
info@usddiscovery.com

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